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Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats: I.Neurophysiological Alterations
https://repo.qst.go.jp/records/43816
https://repo.qst.go.jp/records/43816c8804082-7c3e-4afb-a579-f7809a3716cc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-10-13 | |||||
| タイトル | ||||||
| タイトル | Effects of Prenatal Irradiation with an Accelerated Heavy-Ion Beam on Postnatal Development in Rats: I.Neurophysiological Alterations | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Murakami, Masahiro× Eguchi-Kasai, Kiyomi× Nojima, Kumie× Shang, Yi× Tanaka, Kaoru× Fujita, Kazuko× Herve, Coffigny× Hayata, Isamu× 王 冰× 村上 正弘× 笠井 清美× 野島 久美恵× 尚 奕× 田中 薫× 藤田 和子× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects on postnatal neurophysiological development in offspring were studied following exposure to accelerated carbon ion beams with a LET value of about 13 keV/mm at a dose range from 0.1 Gy to 2.5Gy on the 15th day of gestation of pregnant Wistar rats. The age of appearance of 4 physiologic markers and of acquisition of 5 reflexes was examined preweaningly. Gain in body weight was monitored until postnatal 3 months. Male offspring were evaluated as young adults using two behavioral tests. Effects of X-rays estimated under the same biological endpoints were studied comparatively. For most of the endpoints at early age, significant alteration was not observed in offspring prenatally received 0.1 Gy irradiation of either accelerated carbon ion or X-rays compared to that from the sham-irradiated dams. But all offspring received 2.5 Gy died prior to weaning. Offspring from dams irradiated with accelerated carbon ion generally showed higher incidences of prenatal death and preweaning mortality, markedly delayed accomplishment in their physiological markers and reflexes, and gain in body weight compared to those exposed to X-rays at doses of 0.5 to 2.0 Gy. Significantly reduced ratios of main organ weight to body weight at postnatal ages of 30, 60 and 90 days were also observed within this dose range. Results indicated that irradiation of 0.5 to 2.0 Gy on the fetal age day 15 of rat dose-dependently caused permanent alterations in offspring. The alterations include non-recuperable growth retardation, morphologic malformations in main organs, i.e., microcephaly, diminished reflex attainment, delayed appearance of physiologic markers, and changes in adult behavior. Such exposure to 1.0 to 2.0 Gy of irradiation resulted in growth retardation and behavioral alterations persisting throughout their life. The accelerated carbon ion generally induced higher detrimental effects compared to X-rays. | |||||
| 書誌情報 |
Radiation Research 巻 164, p. 561-566, 発行日 2005 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
