WEKO3
アイテム
Radio-sensitivity of the Cells from Amyotrophic Lateral Sclerosis Model Mice Transfected with Human Mutant SOD1
https://repo.qst.go.jp/records/43762
https://repo.qst.go.jp/records/4376249c84eab-205d-4c02-a3e8-0871b49a4378
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-08-11 | |||||
| タイトル | ||||||
| タイトル | Radio-sensitivity of the Cells from Amyotrophic Lateral Sclerosis Model Mice Transfected with Human Mutant SOD1 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wate, Reika
× Wate, Reika× Takahashi, Sentaro× Kubota, Yoshihisa× Suetomi, Katsutoshi× Kubota, Yoshihisa× Sato, Hiroshi× Okayasu, Ryuichi× et.al× 高橋 千太郎× 久保田 善久× 末冨 勝敏× 久保田 善久× 佐藤 宏× 岡安 隆一 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to clarify the possible involvement of oxidative damage induced by ionizing radiation in the onset and/or progression of familial amyotrophic lateral sclerosis (ALS), we studied radio-sensitivity in primary cells derived from ALS model mice expressing human mutant SOD1. The primary mouse cells expressed both mouse and the mutant human SOD1. The cell survival of the transgenic mice (with mutant SOD1), determined by counting cell numbers at a scheduled time after X-irradiation, is very similar to that of cells from wild type animals. The induction and repair of DNA damage in the transgenic cells, measured by single cell gel electrophoresis and pulsed field gel electrophoresis, are also similar to those of wild type cells. These results indicate that the human mutant SOD1 gene does not seem to contribute to the alteration of radio-sensitivity, at least in the fibroblastic cells used here. Although it is necessary to consider the difference in cell types between fibroblastic and neuronal cells, the present results may suggest that ionizing radiation is not primarily responsible for the onset of familial ALS with the SOD1 mutation, and that the excess risks are probably not a concern for radiation diagnosis and therapy in familial ALS patients. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 46, p. 00067-00073, 発行日 2005 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
