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Fractionated irradiation augments inter-strain variation of skin reactions among three strains of mice
https://repo.qst.go.jp/records/43720
https://repo.qst.go.jp/records/43720bd94a9f4-c5de-43fe-8fff-630a4c645dfa
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-07-07 | |||||
| タイトル | ||||||
| タイトル | Fractionated irradiation augments inter-strain variation of skin reactions among three strains of mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oota, Toshie
× Oota, Toshie× Iwakawa, Mayumi× Kitazawa, Chisa× Noda, Shuhei× Yang, Minfu× Gotou, Miyako× Tanaka, Hiroko× Harada, Yoshinobu× Imai, Takashi× 太田 敏江× 岩川 眞由美× 北沢 知佐× 野田 秀平× 中渡 美也子× 田中 裕子× 原田 良信× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The multifraction regimens commonly used in conventional clinical radiotherapy are largely based on radiobiological experiments. However, no experimental reports on skin reactions focusing on inter-strain differences have displayed clinical relevance to the fractionated dose schedule. In this study, mice of inbred strains A/J, C57BL/6J, and C3H/HeMs were used to reveal inter-strain difference after multifractionated irradiation. Irradiation was performed daily at graded doses of 30-60 Gy total doses, with 10 fractions of 3-6 Gy. Acute skin reactions following irradiation were scored for 50 days after irradiation. Dividing a dose into a number of fractions obviously spared skin damage in the three strains of mice. No mouse exhibited a skin damage score more than 1.5, while single dose irradiation resulted in skin damage scores up to 3. The three different strains, however, showed varying susceptibility to fractionated irradiation within the range under 1.5. C3H/HeMs did not display any skin reaction after irradiation with 40 Gy total dose, while C57BL/6J and A/J demonstrated various skin reactions. Different latent periods of damage were also observed among the strains after irradiation at each dose. Our data suggest that genetic factors cause obvious variations in severity of damage and latent period after fractionated irradiation. |
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| 書誌情報 |
Journal of Radiation Research 巻 45, 号 4, p. 515-519, 発行日 2004-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
