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Differences in pO2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation
https://repo.qst.go.jp/records/43592
https://repo.qst.go.jp/records/43592ddb30fdd-041a-4aad-a565-8c94042f65e3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-01-07 | |||||
| タイトル | ||||||
| タイトル | Differences in pO2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukawa, Takeshi
× Fukawa, Takeshi× Takematsu, Koji× Oka, Kotaro× Koike, Sachiko× Ando, Koichi× Kobayashi, Hirosuke× Tanishita, Kazuo× 扶川 武志× 小池 幸子× 安藤 興一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We measured and compared the oxygen partial pressure (pO2) profiles in experimental tumors after irradiation with carbon ions and with X-rays. The NFSa fibrosarcomas grown in the hind legs of C3H male mice received isoeffect single doses of carbon ions or X-rays. Coaxial oxygen microelectrodes of high spatial resolution were inserted into the tumor with 20 micrometer steps by a computerized micromanipulator. The number of pO2 peaks that reached 15 mmHg were at least 0.45 per 3,000 micrometer in unirradiated tumors and significantly increased to 1.55 per 3,000 micrometer as early as day 1 of carbon-ion irradiation (p<0.001). The tumors that received X-ray irradiation also significantly increased pO2 peaks, but as late as day 3. The time course of pO2 peak appearance in the present study coincides with a previous report where reoxygenation was measured by paired growth delay assay. The pO2 peaks appeared selectively in peripheral regions of X-ray irradiated tumors, but they appeared rather homogeneously in the tumor after carbon-ion irradiation. It is concluded that carbon-ion irradiation reoxygenated the NFSa fibrosarcomas earlier in time and deeper in space than the X-ray irradiation did. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 45, 号 2, p. 303-308, 発行日 2004-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
