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The melanocortin receptor-1 gene but not the proopiomelanocortin gene is expressed in melanoblasts and contributes their differentiation in the mouse skin
https://repo.qst.go.jp/records/43581
https://repo.qst.go.jp/records/435812f2a74b0-b63e-44f7-a75c-2cb1515d367a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-12-28 | |||||
| タイトル | ||||||
| タイトル | The melanocortin receptor-1 gene but not the proopiomelanocortin gene is expressed in melanoblasts and contributes their differentiation in the mouse skin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Takeuchi, Sakae× et.al× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Alpha-melanocyte stimulating hormone (a-MSH) added to serum-free primary culture of melanoblasts derived from epidermal cell suspensions of 0.5-day-old C57BL/10JHir mice induced their differentiation. The analysis using the reverse transcription-polymerase chain reaction showed that the expression of the melanocyte-specific a-MSH receptor gene, melanocortin receptor-1 (MC1-R) had already initiated before addition of a-MSH, and, in addition, no up-regulation of the MC1-R gene was observed after addition of a-MSH. However, no expression of the proopiomelanocortin (POMC) gene was observed before and after addition of a-MSH. The expression of the MC1-R and POMC genes in the epidermis and dermis of the dorsal skin was surveyed from 13-day-old embryos to 5.5-day-old neonates. The expression of the MC1-R gene was first observed in the epidermis of 13-day-old embryos, and gradually increased up to 0.5 days after birth, and thereafter remained constant. By contrast, the expression of the MC1-R gene in the dermis was first observed in 16-day-old embryos, and gradually increased up to 3.5 days after birth, and thereafter remained constant. However, no expression of the POMC gene was observed in the epidermis and dermis of the dorsal skin at all ages of mice tested. These results suggest that the expression of the MC1-R gene, but not of the POMC gene plays an important role in the regulation of melanocyte differentiation in the mouse skin. | |||||
| 書誌情報 |
Pigment Cell Research 巻 17, 号 6, p. 627-635, 発行日 2004-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0893-5785 | |||||
