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Cytological basis for enhancement of radiation-induced mortality by Friend leukaemia virus infection
https://repo.qst.go.jp/records/43574
https://repo.qst.go.jp/records/43574e0628e13-185e-4444-8645-6245b8aac66e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-12-21 | |||||
| タイトル | ||||||
| タイトル | Cytological basis for enhancement of radiation-induced mortality by Friend leukaemia virus infection | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tanaka, Kaoru
× Tanaka, Kaoru× Watanabe, Keiko× Yamaguchi, Shuichi× Hasegawa, Maki× Kitagawa, Masanobu× Aizawa, Shirou× 田中 薫× 渡辺 恵子× 山口 修一× 長谷川 真紀× 北川 昌伸× 相澤 志郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To analyze the cytological basis for enhancement of radiation-induced mortality by Friend leukemia virus infection. Material and Methods: Cellularity in hematopoietic tissues of C3H mice infected with FLV and/or whole-body-irradiated was examined. Results: When mice were treated with a sublethal dose (3 Gy) of irradiation at 1 week after virus infection, most manifested a severe loss of cellularity in spleen, bone marrow and peripheral blood 2 weeks after irradiation. More than 90% of the mice died within 1 month post-irradiation. However, this deleterious effect of virus infection on the survival of irradiated mice was observed only when they were irradiated at around 1 week after virus inoculation. Strain difference in the sensitivity to this effect were observed among virus-sensitive strains of mice. Conclusions: These results indicate that Friend leukemia virus infection can cause enhancement of radiation sensitivity of hematopoietic cells in host animals in a restricted manner in terms of genetic background and the interval between infection and irradiation. |
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| 書誌情報 |
International Journal of Radiation Biology 巻 80, 号 9, p. 673-681, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
