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Chromosomal Aberrations Induced by High-Energy Iron Ions With Shielding
https://repo.qst.go.jp/records/43521
https://repo.qst.go.jp/records/43521ba39a707-5205-4ba0-8252-ebb9f18ec777
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-10-26 | |||||
| タイトル | ||||||
| タイトル | Chromosomal Aberrations Induced by High-Energy Iron Ions With Shielding | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Grossi, Giafranco
× Grossi, Giafranco× Durante, Marco× Gialanella, G× Antonella, Pugliese Malia× Scampoli, P× Furusawa, Yoshiya× Kanai, Tatsuaki× Matsufuji, Naruhiro× 古澤 佳也× 金井 達明× 松藤 成弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Biophysical models are commonly used to evaluate the effectiveness of shielding in reducing the biological damage caused by cosmic radiation in space flights. To improve and validate these codes biophysical experiments are needed. We have measured the induction of chromosomal aberrations in human peripheral blood lymphocytes exposed in vitro to 500 MeV/n iron ion beams (dose range 0.1_1 Gy) after traversing shields of different material (lucite, aluminium, or lead) and thickness (0_11.3 g/cm2). For comparison, cells were exposed to 200 MeV/n iron ions and to X-rays. Chromosomes were prematurely condensed by a phosphatase inhibitor (calyculin A) to avoid cell-cycle selection produced by the exposure to high-LET heavy-ion beams. Aberrations were scored in chromosomes 1, 2, and 4 following fluorescence in situ hybridization. The fraction of aberrant lymphocytes has been evaluated as a function of the dose at the sample position, and of the fluence of primary 56Fe ions hitting the shield. The influence of shield thickness on the action cross-section for the induction of exchange-type aberrations has been analyzed, and the dose average-LET measured as a function of the shield thickness. These preliminary results prove that the effectiveness of heavy ions is modified by shielding, and the biological damage is dependent upon shield thickness and material. | |||||
| 書誌情報 |
Advances in Space Research 巻 34, p. 1358-1361, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0273-1177 | |||||
