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In vivo oxygen radical generation in the skin of the protoporphyria model mouse with visible light exposure: an L-band ESR study
https://repo.qst.go.jp/records/43500
https://repo.qst.go.jp/records/435007cb24d99-a429-455b-a77a-069a6ad2aefa
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-10-08 | |||||
| タイトル | ||||||
| タイトル | In vivo oxygen radical generation in the skin of the protoporphyria model mouse with visible light exposure: an L-band ESR study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takeshita, Keizo
× Takeshita, Keizo× Takajo, Tokuko× Hirata, Hiroshi× Ono, Mitsuhiro× Utsumi, Hideo× 竹下 啓蔵× 小野 光弘× 内海 英雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although oxygen radicals are thought to play a key role in the skin injury that is caused by protoporphyria, there is no direct evidence of generation of these radicals in vivo. This study measured the generation of oxygen radicals caused by visible light non-invasively in the skin of griseofulvin-induced protoporphyria model mice, using an in vivo ESR spectrometer equipped with a surface-coil-type resonator that could detect radicals within about 0.5 mm of the skin surface. A durable nitroxyl radical was administered intravenously as a probe. Light irradiation enhanced the decay of the nitroxyl signal in griseofulvin-treated mice, while light irradiation did not enhance the signal decay in control mice. The enhanced signal decay was completely suppressed by intravenous administration of hydroxyl radical scavengers, superoxide dismutase or catalase, or the intraperitoneal administration of desferrioxamine. The enhanced signal decay with illumination was reversible, and quickly responded to turning the light on and off. These observations suggest that the hydroxyl radical is generated via an iron-catalyzed reaction in the skin of the protoporphyria model mouse under light. This paper reports the in vivo detection of oxygen radicals in skin and demonstrates, for the first time, the specific generation of oxygen radicals in response to light irradiation of the skin of protoporphyria model mice. | |||||
| 書誌情報 |
Journal of Investigative Dermatology 巻 122, 号 6, p. 1463-1470, 発行日 2004-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-202X | |||||
