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Use of Rubidium, Manganese, and Zinc as Tracers to Measure Intestinal Permeability by PIXE Analysis
https://repo.qst.go.jp/records/43460
https://repo.qst.go.jp/records/4346006068759-daf1-4276-9f85-aba971063454
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-08-04 | |||||
| タイトル | ||||||
| タイトル | Use of Rubidium, Manganese, and Zinc as Tracers to Measure Intestinal Permeability by PIXE Analysis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakao, Keitaro
× Nakao, Keitaro× Suzuki, Yasuo× Imaseki, Hitoshi× Joshima, Hisamasa× Tamanoi, Itsurou× Saito, Yasushi× 今関 等× 上島 久正× 玉野井 逸朗 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Intestinal permeability has been suggested to be closely linked with the etiology or activity of Crohn's disease. However, current methods for measurement of intestinal permeability are too laborious for routine examination, as they require urine collection and/or use of radioisotopes. The present study was performed to develop a more convenient and safer method for assessing intestinal permeability using blood samples rather than urine. Rats with indomethacin-induced enteritis were orally administered Rb, Mn, and Zn as tracers. Intestinal permeability was determined by assaying the levels of Rb, Mn, and Zn in blood samples by particle-induced X-ray emission (PIXE). The distributions of Rb, Mn, and Zn in the small intestine after administration were analyzed by micro-PIXE. The conventional PIXE analysis showed that the levels of Rb and Zn in the blood in the enteritis group were correlated with the grade of enteritis. The micro-PIXE analysis showed that Rb, Mn, and Zn were translocated into the wall of the proximal small intestine 5 min after administration, and this effect was more conspicuous in the enteritis group than in controls. Analysis of blood or small intestine tissue samples using the PIXE allows determination of both intestinal permeability and the route of permeation. | |||||
| 書誌情報 |
Biological Trace Element Research 巻 98, 号 1, p. 27-44, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0163-4984 | |||||
