WEKO3
アイテム
Identification of a New G-to-A Transition Mutation at Nucleotide Position 129 of the Xrcc4 Gene in Ionizing Radiation-hypersensitive Mutant LX830 Cells.
https://repo.qst.go.jp/records/43369
https://repo.qst.go.jp/records/43369cc5e8326-e7aa-47f9-8023-616050410c2f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-03-30 | |||||
| タイトル | ||||||
| タイトル | Identification of a New G-to-A Transition Mutation at Nucleotide Position 129 of the Xrcc4 Gene in Ionizing Radiation-hypersensitive Mutant LX830 Cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Itsukaichi, Hiromi
× Itsukaichi, Hiromi× Mori, Masahiko× Nakamura, Atsuko× Sato, Koki× 五日市 ひろみ× 森 雅彦× 中村 篤子 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The mouse lymphoma cell line LX830 is an X-ray-hypersensitive mutant. Complementation tests between LX830 cells and radiation-sensitive mutants of M10 (Xrcc4 deficient cells) or SX10 (DNA ligase IV deficient cells) cells showed that M10 cells did not complement LX830 cells, but SX10 cells did, suggesting that LX830 cells would belong to the X-ray-cross complementation group (XRCC4). A sequence analysis of Xrcc4 cDNA in LX830 cells disclosed a transition of G to A at nucleotide position 129, which resulted in a change of tryptophan (43) to a termination codon. Transfection of the mouse Xrcc4 cDNA rescued the X-ray sensitivity of the mutant cells. LX830 is an Xrcc4-deficient cell line bearing a terminationo codon in exon 2 of the Xrcc4 gene and no wild-type Xrcc4 gene. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 44, p. 353-358, 発行日 2004 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
