WEKO3
アイテム
Metal Contents in the Liver of Patients with Chronic Liver Disease Caused by Hepatitis C Virus
https://repo.qst.go.jp/records/43347
https://repo.qst.go.jp/records/4334756340726-6bb7-415e-8c13-4f94a9fbf3e1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-02-09 | |||||
| タイトル | ||||||
| タイトル | Metal Contents in the Liver of Patients with Chronic Liver Disease Caused by Hepatitis C Virus | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ebara, Masaaki
× Ebara, Masaaki× Fukuda, Hiroyuki× Yoshikawa, Masaharu× Sugiura, Nobuyuki× Yukawa, Masae× et.al× 江原 正明× 吉川 正治× 杉浦 信之× 湯川 雅枝 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aims: The aim of this study was to investigate the relationship between trace metals and the prevalence of hepatocellular carcinoma (HCC) in patients with chronic hepatic cirrhosis caused by hepatitis C virus (HCV). Methods: We measured the contents of copper, iron, and zinc in HCC tissue (n=112), dysplastic nodules (n=7), and liver parenchyma in patients with (n=112) and without (12; 7 with grade F3 fibrosis, 5 with grade F4 fibrosis) HCC. Metals were quantified in thin-needle biopsy specimens using the particle-induced X-ray emission method (PIXE). Results: Copper level in liver parenchyma was higher in patients with HCC than in those without HCC (p<0.01), while there was no such difference in hepatic iron. In patients with grade F4 fibrosis, copper content in the liver parenchyma was higher in the presence of HCC than in its absence (p<0.05).Multiple regression analysis showed that the only factor significantly associated with the coexistence of HCC in HCV-positive patients with chronic liver disease was the copper level in the liver parenchyma. Conclusions: Hepatic copper overload may contribute to the development of HCC in HCV-positive patients with chronic hepatitis or cirrhosis. | |||||
| 書誌情報 |
Oncology 巻 65, 号 4, p. 323-330, 発行日 2003 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0030-2414 | |||||
