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A new method of estimating the cytotoxic effects of suspended particulate matter on cultured alveolar macrophages in vitro
https://repo.qst.go.jp/records/43285
https://repo.qst.go.jp/records/4328563761375-eeb1-4965-b6a4-fa0fa7e40423
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-27 | |||||
| タイトル | ||||||
| タイトル | A new method of estimating the cytotoxic effects of suspended particulate matter on cultured alveolar macrophages in vitro | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahashi, Sentaro
× Takahashi, Sentaro× Kubota, Yoshihisa× Okinaga, Kiyo× Furuya, Keiichi× 高橋 千太郎× 久保田 善久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A new method has been devised for evaluating the cytotoxicity of suspended particulate matters in vitro.It uses the proliferative capacity of mouse alveolar macrophages,estimated by the uptake of 3H-tymidine,as an index of cytotoxicity,and provides a simple and rapid of means of evaluating the cytotoxicity of suspended particulate matter collected on a filter by a personal air sampler.A significant decrease in 3H-tymidine uptake(an indication of impaired proliferation)could be detected in the range of approximately 0.31 to 1.03 mug of nickel sulfide particles per square centimeter of culture dish,suggesting the relatively great sensitivity of this method to particulate toxicants.A preliminary application of this method to suspended particulate matter collected in an urban atmosphere indicated that 3 hours of sampling,corresponding to that in about 0.72 cubic meters of air,were sufficient for evaluation of toxicity by this method. | |||||
| 書誌情報 |
Toxicology Mechanisms and Methods 巻 12, p. 169-180, 発行日 2002 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1537-6516 | |||||
