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Rhenium-188-HEDP Therapy for the Palliation of Pain Due to Osseous Metastases in Lung Cancer Patients
https://repo.qst.go.jp/records/43278
https://repo.qst.go.jp/records/43278661849e1-922c-4674-afd0-62d02fa34857
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-21 | |||||
| タイトル | ||||||
| タイトル | Rhenium-188-HEDP Therapy for the Palliation of Pain Due to Osseous Metastases in Lung Cancer Patients | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Hong
× Zhang, Hong× Mei, Tian× Tanada, Shuji× Endou, Keigo× et.al× 張 宏× 棚田 修二× 遠藤 啓吾 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Rhenium-188-hydroxyethylidine diphosphonate(188Re-HEDP) is a novel and attractive radiopharmaceutical that localizes in areas of osseous metastases and emits beta particles with enerty sufficient to be therapeutically useful. The aim of this study is to evaluate the effectiveness of 188Re-HEDP in patients with lung cancer for the palliation of painful osseous metastases. Intravenous administration of activities rangiong between 1.15 GBq(31 mCi) and 4.6GBq(124 mCi) of 188Re-HEDP was given to each of 30 patients with painful osseous metastases from lung cancer. The patients were clinically followed at weekly intervals for the first 2 months, and monthly thereafter up to 1 year.Hematologic testing was performed before treatment and thereafter for 6 weeks. Pain response was scored by a four-point pain-rating scale as complete, marked, mild, and no response. Prompt and significant relief of bone pain occurred in 80percent with no significant side-effects or hematopoietic toxicity. Forty-six percent(46percent)of the patients discontinued analgesics after treatment. This clical study indicated that 188Re-HEDP can offer significant pain palliation and is a useful radiopharmaceutical for treating painful osseous metastases from lung cancer. | |||||
| 書誌情報 |
Cancer Biotherapy & Radiopharmaceuticals 巻 18, 号 5, p. 719-725, 発行日 2003 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1084-9785 | |||||
