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Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in Male NC/Nga mice
https://repo.qst.go.jp/records/43255
https://repo.qst.go.jp/records/43255a45b10fd-7c3e-4c27-92ee-e602ab10cacd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-10 | |||||
| タイトル | ||||||
| タイトル | Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in Male NC/Nga mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujimaki, Hidekazu
× Fujimaki, Hidekazu× Nohara, Keiko× Kobayashi, Takahihiro× Suzuki, Keiko× Eguchi-Kasai, Kiyomi× Tsukumo, Shinichi× Kijima, Mika× Tohyama, Chiharu× 鈴木 桂子× 笠井 清美 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces immunosuppression in humans and animals. However, the effect of TCDD on Th2-type immune responses such as allergic reactions has been unclear. Using NC/Nga mice that developed atopic dermatitis-like skin lesions with marked elevation in plasma of total IgE when bred under conventional conditions, we investigated the effects of a single oral dose of TCDD on immune responses. NC/Nga mice received a single oral dose (0 or 20 microg/kg body weight) of TCDD. On day 7, treatment with TCDD alone decreased the cellularity of thymus. However, treatment with TCDD modified the cellularity of spleens and mesenteric lymph nodes (MLNs) but not of the thymus on day 28. When NC/Nga mice received ip immunization with OVA and alum on the same day as the TCDD treatment (0, 5, or 20 microg/kg body weight), TCDD markedly suppressed the concentrations of Th2-type cytokines (e.g., IL-4 and IL-5) in culture supernatants of spleen cells, whereas IFN-gamma production significantly increased. TCDD exposure reduced anti-OVA and total IgE antibody titers in plasma and did not induce the development of atopic dermatitis-like lesions in the pinnae or dorsal skin of NC/Nga mice. These results suggest that in NC/Nga mice, exposure to TCDD may impair the induction of Th2-type immune responses. | |||||
| 書誌情報 |
Toxicological Sciences 巻 66, p. 117-124, 発行日 2002 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1096-6080 | |||||
