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Molecular Characterization of Ionizing Radiation-Hypersensitive Mutant M10 cells
https://repo.qst.go.jp/records/43142
https://repo.qst.go.jp/records/43142f608f558-3c0a-401c-ab66-40ebdbbe7269
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-09-01 | |||||
| タイトル | ||||||
| タイトル | Molecular Characterization of Ionizing Radiation-Hypersensitive Mutant M10 cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mori, Masahiko
× Mori, Masahiko× Itsukaichi, Hiromi× Nakamura, Atsuko× Sato, Koki× 森 雅彦× 五日市 ひろみ× 中村 篤子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | An ionizing radiation-sensitive mutant derivative of mouse lymphoma L5178Y cell, M10, is defective in rejoining DNA double-strand breaks (DSBs). The complementation test and the results of chromosome transfer suggested that M10 may belong to X-ray cross-complementation (XRCC) group 4. In the present study, sequence analysis of Xrcc4 cDNA in M10 cells disclosed a transversion of A (370) to T, which result in a change of arginine (124) to a termination codon. Interestingly, the mutation occurred in one allele and the transcripts of the Xrcc4 gene were expressed exclusively from the mutant allele. Transfection of M10 cells with the murine Xrcc4 cDNA completely rescued X-ray sensitivity of the mutant cells. M10 is a novel Xrcc-4-deficient cell line. | |||||
| 書誌情報 |
DNA Repair : A Section of Mutation Research 巻 487, p. 85-92, 発行日 2000-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0921-8777 | |||||
