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The Specific Induction of Osteosarcomas in Different Mouse Strains after Injections of 239Pu Citrate
https://repo.qst.go.jp/records/43123
https://repo.qst.go.jp/records/431237ddeebad-607a-429a-a45a-ca93176b3e59
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-07-25 | |||||
| タイトル | ||||||
| タイトル | The Specific Induction of Osteosarcomas in Different Mouse Strains after Injections of 239Pu Citrate | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oghiso, Yoichi
× Oghiso, Yoichi× Yamada, Yutaka× 小木曽 洋一× 山田 裕 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Lifetime bone tumor induction by the injection of a bone-seeking alpha emitter, 239Pu citrate, was compared among 630 female mice from three strains (C3H/He, C57BL/6 and B6C3F1) showing different genetic backgrounds for carcinogenesis. Bone tumors, mostly osteosarcomas, appeared early during the period from 200 to 600 days after the injection, showing an almost similar dose responsiveness with a peak incidence of 50% to 63% at skeletal doses of 2-3 Gy, in all mouse strains. The primary sites of bone tumors from these strains were also predominantly distributed in 80% to 90% of the skeletal bones, which had well-developed trabecular bone surfaces and large vascular sinusoids. The frequency of lymphoid neoplasms was significantly lower than the control values, and some appeared earlier at the higher injected doses than those of the controls. Fewer or no myeloid leukemias were found in all the control and injected animals, and the incidences of other solid tumors decreased, reaching zero at doses where the maximurn incidences of bone tumors were noted. These findings indicate that osteosarcoma is the only specific turnor commonly observed among different mouse strains following the injection of soluble plutoniurn compounds. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 44, p. 125-132, 発行日 2003-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
