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The involvement of cell cycle checkpoint-mutations in the mutagenesis induced in Drosophila by a longer wavelength light band of solar UV
https://repo.qst.go.jp/records/43098
https://repo.qst.go.jp/records/430983e504858-f48a-40e0-a32c-ba6dd1e81f78
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-05-30 | |||||
| タイトル | ||||||
| タイトル | The involvement of cell cycle checkpoint-mutations in the mutagenesis induced in Drosophila by a longer wavelength light band of solar UV | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Toyoshima, Megumi
× Toyoshima, Megumi× Takinami, Shogo× Hieda, Kotaro× Furusawa, Yoshiya× Negishi, Tomoe× 檜枝 光太郎× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Solar ultraviolet radiation is considered to be injurious rather than necessary for most organisms living on the earth. It is reported that the risk of skin cancer in humans increased by the depletion of the ozone layer. We have examined the genotoxicity of solar ultraviolet, especially the longer wavelengths light, using Drosophila. Recently, we have demonstrated that light of wavelengths up to 340 nm is mutagenic on Drosophila larvae. Using an excision repair-deficient Drosophila strain (mus201), we have obtained results suggesting that the lesion caused in larvae by the 320 nm-light irradiation may be similar to the damage induced by irradiation at 310 nm, and that light of 330 and 340 nm may induced damage different from that induced by 310 and 320 nm-light. To examine the difference in DNA damage induced by light of particular wavelength, we performed monochromatic irradiation on larvae of two Drosophila strains; one excision repair-deficient (mei-9) and another postreplication repair-deficient (mei-41). 310 and 320 nm-light was more mutagenic in the mei-9 strain than mei-41, whereas 330 and 340 nm-light was more mutagenic in mei-41 than in mei-9. It is demonstrated that the mei-41 gene is a homologue of the human atm gene which is responsible for a cell cycle checkpoint. This result suggests that 310-320 nm-light induces DNA damage that is subject to nucleotide excision repair (NER) and that 3300-360 nm-light causes damage to be recognized by the cell cycle checkpoint but it is not repairable by NER. | |||||
| 書誌情報 |
Photochemical and Photobiological Sciences 巻 1, p. 178-183, 発行日 2002-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1474-905X | |||||
