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Two reaction sites of spin label, TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), with hydroxyl radical
https://repo.qst.go.jp/records/43088
https://repo.qst.go.jp/records/430886d417075-376a-496f-a82f-0da93f441a78
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-05-19 | |||||
| タイトル | ||||||
| タイトル | Two reaction sites of spin label, TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), with hydroxyl radical | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Saito, Keita
× Saito, Keita× Takeshita, Keizo× Ueda, Junichi× Ozawa, Toshihiko× 齋藤 圭太× 竹下 啓蔵× 上田 順市× 小澤 俊彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The exposure of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) to hydroxyl radical (.OH) led to the appearance of a new triplet ESR signal along with a reduction in the intensity of the TEMPOL signal. The observed spectrum was in good agreement with the spectrum simulated with 4-oxo-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPON) and TEMPOL, and the addition of sodium borohydride to the product solution led to the disappearance of the new signal. These indicate the formation of TEMPON during the reaction. A comparison of the concentration of TEMPON formed with that of nitroxyl compounds which lost the ESR signal showed that the rate of TEMPON formation is one-twelfth that of the paramagnetism-loss caused by .OH. These results indicate that the 4-position of TEMPOL scavenges .OH to compensate for a decline in the scavenging activity of the nitroxyl group by the faster reaction with .OH, although the reaction is relatively slow. | |||||
| 書誌情報 |
Journal of Pharmaceutical Sciences 巻 92, p. 275-280, 発行日 2003 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-3549 | |||||
