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Immunohistochemical study on cellular origins of rat lung tumors induced by inhalatiion exposures to pultonium dioxide aerosols as compared to those by X-ray irradiation.
https://repo.qst.go.jp/records/43026
https://repo.qst.go.jp/records/430265eda4d90-bf21-4c93-ae4e-e836a94abec5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-12-26 | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical study on cellular origins of rat lung tumors induced by inhalatiion exposures to pultonium dioxide aerosols as compared to those by X-ray irradiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oghiso, Yoichi
× Oghiso, Yoichi× Yamada, Yutaka× 小木曽 洋一× 山田 裕 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Immunohistochemical examinations were performed on rat pulmonary tumors induced by inhalation exposures to ^239^PuO2 aerosols, or by X-ray-irradiation to identify and compare cellular origins or, in turn, target cells at risk for radiation carcinogenesis. Both plutonium-induced and X-ray-induced pulmonary tumors appeared to occur from the lower respiratory tract epithelium through bronchioles into alveoli, and were histopathologically diagnosed as adenoma, adenocarcinoma, adenosquamous carcinoma, and squamous cell carcinoma. Immunohistochemical staining of neoplastic lesions using rabbit polyclonal antibodies to rat surfactant apoprotein A specific for alveolar type II pneumocytes, and Clara cell antigen specific for nonciliated bronchiolar Clara cells, showed that most of the adenomatous and adenocarcinomatous lesions from plutonium-exposed or X-irradiated rats were positive for either or both antigens, while, in contrast, adenosquamous and squamous lesions were mostly negative for both antigens. Even though there were some differences in the proportions and distributions of immunoreactive cells between plutonium-and X-ray-induced tumors and among neoplastic lesions, the results indicate that radiation-induced pulmonary adenomas and adenocarcinomas mostly originate from either alveolar type II pneumocytes or bronchiolar Clara cells, while adenosquamous and squamous carcinomas may be derived from the other epithelial cell components, or might have lost specific antigenicith during their transforming differentiation. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 43, p. 301-311, 発行日 2002-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
