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Simultaneous exposure of mammalian cells to heavy ions and X-rays
https://repo.qst.go.jp/records/43014
https://repo.qst.go.jp/records/430147ba45252-ed74-46d4-8e94-70658999fe9c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-12-12 | |||||
| タイトル | ||||||
| タイトル | Simultaneous exposure of mammalian cells to heavy ions and X-rays | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Furusawa, Yoshiya
× Furusawa, Yoshiya× Aoki, Mizuho× Durante, Marco× 古澤 佳也× 青木 瑞穂 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Crews of space missions are exposed to a mixed radiation field, including sparsely and densely ionizing radiation. To determine the biological effectiveness of mixed high-/low-LET radiation fields, mammalian cells were exposed in vitro simultaneously to X-rays and heavy ions, accelerated at the HIMAC accelerator. X-ray doses ranged from 1 to 11 Gy. At the same time, cells were exposed to either 40Ar (550 MeV/n, 86 keV/mm), 28Si (100 MeV/n, 150 keV/mm), or 56Fe (115 MeV/n, 442 keV/mm) ions. Survival was measured in hamster V79 fibroblasts. Structural aberrations in chromosome 2 were measured by chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization in isolated human lymphocytes. For argon and silicon experiments, measured damage in the mixed radiation field was consistent with the value expected using an additive function for low- and high-LET separated data. A small deviation from a simple additive function is observed with very high-LET iron ions combined to X-rays. | |||||
| 書誌情報 |
Advances in Space Research 巻 30, p. 877-884, 発行日 2002-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0273-1177 | |||||
