WEKO3
アイテム
Preclinical biological assessment of proton and carbon ion beams at Hyogo Ion Beam Medical Center
https://repo.qst.go.jp/records/43004
https://repo.qst.go.jp/records/4300471b2f3ee-178a-4093-af4c-4b5e894d6353
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-11-13 | |||||
| タイトル | ||||||
| タイトル | Preclinical biological assessment of proton and carbon ion beams at Hyogo Ion Beam Medical Center | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kagawa, Kazufumi
× Kagawa, Kazufumi× Murakami, Masao× Hishikawa, Yoshio× Abe, Mitsuyuki× Akagi, Takashi× Yanou, Toshihiro× Kagiya, Gou× Furusawa, Yoshiya× Ando, Koichi× Nojima, Kumie× Aoki, Mizuho× Kanai, Tatsuaki× 香川 一史× 村上 昌雄× 菱川 良夫× 阿部 光幸× 赤城 卓× 鍵谷 豪× 古澤 佳也× 安藤 興一× 野島 久美恵× 青木 瑞穂× 金井 達明 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To assess the biologic effects of proton and carbon ion beams before clinical use. Methods and Materials: Cultured cells from human salivary gland cancer (HSG cells) were irradiated at 5 points along a 190 MeV per nucleon proton and a 320 MeV per nucleon carbon ion beam, with Bragg peaks modulated to 6 cm widths. A linac 4 MV X-ray was used as a reference. Relative biologic effectiveness (RBE) values at each point were calculated from survival curves. Cells were also irradiated in a cell-stack phantom to identify that localized cell deaths were observed at predefined depth. Total body irradiation of C3H/He mice was performed, and the number of regenerating crypts per jejunal section was compared to calculate intestinal RBE values. For carbon ion and referential 4 MV X-ray beams, mouse right legs were irradiated by four-fractional treatment and followed up for skin reaction scoring. Results: RBE values calculated from cell survival curves at the dose that would reduce cell survival to 10% (D10) ranged from 1.01 to 1.05 for protons and from 1.23 to 2.56 for carbon ions. The cell-stack phantom irradiation revealed localized cell deaths at predefined depth. The intestinal RBE values ranged from 1.01 to 1.08 for protons and from 1.15 to 1.88 for carbon ions. The skin RBE value was 2.16 at C320/6 cm spread-out Bragg peak (SOBP) center. Conclusion: The radiobiologic measurements of proton and carbon ion beams at Hyogo Ion Beam Medical Center are consistent with previous reports using proton beams in clinical settings and carbon ion beams with similar linear energy transfer (LET) values. |
|||||
| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 54, p. 928-938, 発行日 2002-03 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
