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Effects of synthetic dopamine-melanins on oxygen radical formation induced by metal ions with dopamine.
https://repo.qst.go.jp/records/42905
https://repo.qst.go.jp/records/4290574bf3495-9054-4c8c-ba58-651b47c63d76
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-06-07 | |||||
| タイトル | ||||||
| タイトル | Effects of synthetic dopamine-melanins on oxygen radical formation induced by metal ions with dopamine. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimura, Shinzo
× Kimura, Shinzo× Kurasaki, Masaaki× Saito, Takeshi× Ito, Keizo× Hosokawa, Toshiyuki× Okabe, Masashi× Shiraishi, Kunio× Niioka, Tadashi× 木村 真三× 白石 久二雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To understand the possible physiological roles of the neuromelanins, we examined effects of synthetic dopamine-melanins on oxygen radical formation by metal ions with dopamine. Oxygen radical formation was detected by DNA cleavage analysis. Addition of metal-free synthetic dopamine-melanins inhibited DNA cleavage induced by Fe or Cu ions with dopamine. On the other hand, in the presence of dopamine, dopamine-melanins loaded with Cu and Fe induced DNA cleavage without addition of free metal ions. It was clarfied that dopamine-melanins loaded with Cu and Fe generated hydroxyl radicals in the presence of dopamine, on the basis of the findings thet catalase and mannitol inhibited the DNA cleavage. Our results suggest that metal-free neromalanins inhibit hydroxyl radical formation induced by ions with dopamine by sequestering metal ions. | |||||
| 書誌情報 |
Neuroscience Research Communications 巻 29, 号 1, p. 31-40, 発行日 2001 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0893-6609 | |||||
