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Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum:comparison of [11C] raclopride, [11C] nemonapride and [11C] N-methylspiperone
https://repo.qst.go.jp/records/42893
https://repo.qst.go.jp/records/42893b79ca040-7e18-4ac3-93bb-885d2a495f0b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-06-03 | |||||
| タイトル | ||||||
| タイトル | Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum:comparison of [11C] raclopride, [11C] nemonapride and [11C] N-methylspiperone | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishiwata, Kiichi
× Ishiwata, Kiichi× Ogi, Nobuo× Hayakawa, Nobutaka× Umegaki, Hiroyuki× Nagaoka, Tsukasa× Oda, Keiichi× Toyama, Hinako× Endo, Kazutoyo× Tanaka, Akira× Senda, Michio× 石渡 喜一× 織田 圭一× 外山 比南子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | With [11C]raclopride,[11C]nemonapride and [11C]N-methylspiperone,degeneration of dopamine D2-like receptors in the unilaterally quinolinic acid-lesioned rats was evaluated by positron emission tomography(PET)and ex vivo and in vitro autoradiography.PETshowed a decreaseduptake of [11C]raclopride in the lesioned striatum,but an increased uptake of [11C]nemonapride and [11C]N-methylspiperone despite a decreased binding in vitro.Ex vivo autoradiography showed an increased accumulation of the three ligands in the cortical region overlying the injured striatum,probably enlarging PET signals.PET has the limited potential for evaluating the receptor degeneration in the present animal model. | |||||
| 書誌情報 |
Nuclear Medicine and Biology 巻 29, p. 307-316, 発行日 2002 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
