| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-09-01 |
| タイトル |
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|
タイトル |
Cancer cell membrane-coated superparamagnetic iron oxide nanoparticles as a theranostic platform for magnetic hyperthermia and MR imaging. |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yuchen Yuan
Satoshi Okada
Akira Sumiyoshi
Kazuki Miura
Hiroyuki Nakamura
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as promising theranostic agents owing to their magnetic hyperthermia efficiency and capability as magnetic resonance imaging (MRI) contrast agents. However, achieving sufficient intracellular iron accumulation remains a critical challenge for effective therapy. In this study, we report the development of cancer cell membrane-coated SPIONs (CM-SPIONs) to enhance tumor targeting and intracellular delivery. The CM-SPIONs were prepared using a modified Bangham method in the presence of membranes derived from 4T1 triple-negative breast cancer cells. The resulting nanoparticles exhibited significantly enhanced cellular uptake, reaching an intracellular iron concentration of 6 μg [Fe]/10 cells after 24 h incubation, representing a fivefold increase compared to uncoated SPIONs. Fluorescence imaging revealed predominant localization within lysosomes in the perinuclear region, suggesting that the lysosomal compartment may contribute to the observed AMF-induced cytotoxicity. Upon exposure to an alternating magnetic field (AMF) for 45 min, the CM-SPIONs resulted in 78.6% inhibition of cell proliferation, which was markedly higher than uncoated SPIONs. Furthermore, incubation with CM-SPIONs (0.05 mg [Fe]/mL, 3 h) reduced the T relaxation time from 2.71 s in the untreated cell suspension to 0.48 s, demonstrating significant MRI contrast enhancement. These results indicate that the CM-SPIONs represent a promising platform integrating magnetic hyperthermia with MRI-based cancer theranostics. |
| 書誌情報 |
Bioorganic & medicinal chemistry
巻 143,
p. 118787,
発行日 2026-08
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| 出版者 |
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出版者 |
Elsevier Science |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1464-3391 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
42669251 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.bmc.2026.118787 |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/42669251 |
