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内容記述 |
Objective: There is limited in-vivo evidence for the neuropathological basis in late-onset mood disorders. This study aimed to examine tau and Aβ pathologies in late-onset bipolar disorder (LOBD) and late-onset depression (LOD). Methods: We studied patients with LOBD and LOD which occurred after the age of 40. Twenty-six patients with LOBD aged 68.4 y.o., 21 patients with LOD aged 72.1 y.o., and 46 healthy controls (HCs) aged 66.1 y.o. underwent PET scans with 18F-florzolotau and 11C-PiB. SUVRs were calculated in 64 cortical and subcortical regions and corrected for age and sex. Results: 18F-florzolotau-PET positivity was significantly higher in LOBD (58%) and LOD (67%) individuals than in HCs (22%). LOBD and LOD patients exhibited significantly higher SUVRs than HCs in various cortical areas. Aβ pathology was indicated in 6 LOBD and 8 LOD individuals, but not in HCs. Retention patterns of 18F-florzolotau were heterogenous in both Aβ (+) and Aβ (-) cases, indicating the presence of multiple AD and non-AD pathologies, and were associated with clinical symptoms. Conclusion: Our findings suggest that a significant subset of LOBD and LOD patients harbor tau lesions linked to various AD subtypes and non-AD tauopathies. |
