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内容記述 |
[Background]Vertical oculomotor impairment is a clinical manifestation characteristic of progressive supranuclear palsy (PSP), but its neuropathological basis remains unclarified. [Aims]The purpose of our study was to determine the association between ocular impairment and tau pathologies assessed by positron emission tomography (PET). [Methods] Data were obtained consecutively from February 2018 to August 2021 and included 16 healthy control (HC), 62 PSP, and 11 Parkinson’s disease (PD) subjects with available clinical data. We performed neurological examinations, including assessments of the extent of eye movements (0°-50°). Tau deposits were measured by PET with a radioprobe, 18F-PM-PBB3 (florzolotau). Brain volume was assessed by T1-weighted MRI. The Kruskal-Wallis test was used to analyze comparisons between the three counties. [Results] The PSP group exhibited a significantly lower degree of maximal upward movements (p-value<0.001) and higher tau accumulations in the midbrain (p-value<0.001 ) and globus pallidus (p-value<0.001) than the PD and HC groups. In PSP, there was a moderate correlation between maximal upward eye movements and tau accumulation in the midbrain (Pearson coefficient, -0.377; p-value, 0.013) and globus pallidus (Pearson coefficient, -0.333; p-value, 0.031). Midbrain tegmentum volume was also correlated with maximal upward eye movements (Pearson coefficient 0.332, p-value 0.030). [Conclusions] We demonstrated an implication of tau depositions and related local neuronal loss in vertical oculomotor impairment among PSP patients. |
