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内容記述 |
[Objective]Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive mild TBI (rmTBI). This study assessed the distribution and propagation of tau deposits in living subjects at risk for CTE. [Methods]Twenty-nine former professional boxers with neuropsychiatric symptoms aged 43.4 years (exposure:14.0 years) and 27 healthy subjects aged 45.6 years underwent PET scans with florzolotau and 11C-PiB, brain MRI and plasma biomarker assessments. Thirteen boxers underwent a second PET scan (interval: 2 years). Florzolotau fluorescence and tau-antibody staining were performed on CTE postmortem brains. [Results]Boxers showed a significantly higher florzolotau SUVR in the frontal lobe. Tau deposits assessed by florzolotau SUVR increase in a dose-dependent manner with cumulative brain damage, and were correlated with plasma GFAP levels. Individual differences of florzolotau retentions were associated with clinical manifestations. Longitudinal assessments showed the propagation of tau deposits in the gray matter. Aβ deposition was identified only in one boxer. [Conclusion] Distribution pattern and progression of tau lesions after rmTBI were visualized by PET, consistent with the neuropathology of CTE. |
