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内容記述 |
Radiation-induced adaptive response (RAR) describes a phenomenon in a variety of in vitro and in vivo systems that a low-dose of priming ionizing radiation (IR) reduces detrimental effects of a subsequent challenge IR at higher doses. Among in vivo investigations, studies using the mouse RAR model (Yonezawa Effect) showed that RAR could significantly extenuate high-dose IR-induced detrimental effects such as decrease of hematopoietic stem cells and progenitor cells, acute radiation hematopoietic syndrome, genotoxicity and genomic instability. Meanwhile, it is known that diet intervention has a great impact on health in experimental animal models. In this work, we verified the modifying effects from diet intervention on responses to total body irradiation (TBI) in the mouse RAR model using survival (bone marrow death) and genotoxicity (micronucleated erythrocytes in bone marrow) as endpoints. We confirmed that combination of RAR and mild diet restriction (15% diet cut) could more efficiently reduce radiogenotoxic damage without significant change of the RAR phenotype (suppression of bone marrow death) while mice under unbalanced diet (high-fat diet and low-fat diet) and malnutrition at different extent (25%, 50% and 75% diet cut) show altered responses to TBI and even abolished RAR. These findings demonstrate that nutrition has a big impact on the responses to IR exposure of mice. |
