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Development of a 64Cu-labelled cyclic peptide for PET imaging of urokinase plasminogen activator receptor (uPAR) in melanoma
https://repo.qst.go.jp/records/2003376
https://repo.qst.go.jp/records/2003376131c1737-890e-4807-aa9d-7c3eccd6c67c
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||||||||||||
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| 公開日 | 2026-06-10 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Development of a 64Cu-labelled cyclic peptide for PET imaging of urokinase plasminogen activator receptor (uPAR) in melanoma | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6670 | |||||||||||||||||
| 資源タイプ | conference poster | |||||||||||||||||
| 著者 |
Xie Lin
× Xie Lin
× Hanyu Masayuki
× Nakamoto Kazui
× Yiding Zhang
× Tomomi Kokufuta
× Zhang Ming-Rong
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| 抄録 | ||||||||||||||||||
| 内容記述 | Urokinase-type plasminogen activator receptor (uPAR) is a glycosyl-phosphatidylinositol-anchored glycoprotein on the surface of various cell types that serves to bind the urokinase plasminogen activator and localize the activation reactions in the proteolytic cascade system of plasminogen activation. Increased expression of uPAR is involved in tumor progression in breast cancer, bladder cancer, gastric cancer, and colorectal cancer. uPAR contributes to tumor invasion and metastasis, and is a prognostic factor, particularly in colorectal cancer. PET ligands targeting uPAR have been developed for tumor imaging; however, their clinical translation has been limited due to insufficient stability and S/N ratio. In this study, we aimed to develop a cyclic peptide radioligand [64Cu]N3-PEG3-WX360-Nle for PET imaging of uPAR expression in melanoma (Fig. 1). | |||||||||||||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||||||||||||
| 内容記述 | TERACHM 2026 | |||||||||||||||||
| 発表年月日 | ||||||||||||||||||
| 日付 | 2026-09-23 | |||||||||||||||||
