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Development of two 64Cu-labelled cyclic peptides targeting urokinase plasminogen activator receptor (uPAR) for PET imaging of melanoma
https://repo.qst.go.jp/records/2003314
https://repo.qst.go.jp/records/200331486996625-2ca4-4ec3-b08b-da1f576a4779
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2026-05-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Development of two 64Cu-labelled cyclic peptides targeting urokinase plasminogen activator receptor (uPAR) for PET imaging of melanoma | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6670 | |||||||||
| 資源タイプ | conference poster | |||||||||
| 著者 |
Xie Lin
× Xie Lin
× Zhang Ming-Rong
|
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| 抄録 | ||||||||||
| 内容記述 | Radioligands targeting urokinase-type plasminogen activator receptor (uPAR), which binds urokinase-type plasminogen activator (uPA) and mediates proteolytic cascades involved in cancer invasion and metastasis, have shown promise for cancer diagnosis. However, their clinical translation has been limited by insufficient stability and imaging contrast. This study aimed to develop and evaluate two cyclic peptide-based positron emission tomography (PET) radioligands, [64Cu]PEG3-WX360-Nle and [64Cu]N3-PEG3-WX360-Nle, for stable and selective imaging of uPAR expression (Fig.1). | |||||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||||
| 内容記述 | 2026 SNMMI Annual Meeting | |||||||||
| 発表年月日 | ||||||||||
| 日付 | 2026-05-30 | |||||||||
