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内容記述 |
Dynamic PET imaging can provide molecular information of living subjects as a function of time. However, the temporal resolution of PET is over few seconds, which was too slow to capture rapidely changing brain or cardiac functions. Here, we present an ultrasensitive PET scanner for sub-second dynamic total-body rat imaging. We developed a total-body small animal (TBS) PET scanner with 4-layer depth-of-interaction (DOI) detectors to obtain ultrahigh sensitivity [1]. The TBS PET has 155 mm inner diameter and 325.6 mm axial coverage featuring 45% peak sensitivity with an energy window of 250-750 keV (Fig. 1). Each DOI PET detector consisted of 4-layer 16×16 GSOZ crystals (2.8×2.8×7.5 mm3) and an 8×8 array multi-anode PMT. A bolus of 18F-FDG (21.2 MBq) was injected into an anesthetized rat via tail vein followed by saline injection. Dynamic PET images of a rat were obtained with 0.5 s time frame. In the time activity curves, the time dispersion between the left and right ventricles (1 s) was clearly separated (Fig. 2). In summary, the TBS-PET allowed sub-second dynamic imaging of rat with total-body coverage. |
