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内容記述 |
For mouse neuroimaging, spatial resolution is the most important parameter. However, PET spatial resolution has been limited to over 0.5 mm for the last two decades. Here we present a mouse brain PET scanner that can achieve sub-0.5 mm resolution [1]. The developed PET scanner has a 48 mm ring diameter and 23.4 mm axial field of view (Fig. 1). The PET scanner consists of 32 depth-of-interaction (DOI) detectors. Each DOI detector consists of a staggered 3-layer LYSO crystal array (crystal pitch=0.8 mm, total thickness= 11 mm) and silicon photomultipliers 5×5 array with a 2.4 mm pixel pitch. The physical performance of the PET scanner was evaluated. In vivo mouse brain imaging was performed with 18F-FITM radiotracer. The peak axial sensitivity was 0.65% with an energy window of 440-560 keV. The spatial resolution was 0.67 mm with filtered back projection. With iterative reconstruction algorithm, the 0.45 mm rod structures were clearly resolved (Fig. 2). The thalamus and hypothalamus of a mouse brain were clearly visualized. In summary, the developed PET achieved sub-0.5 mm resolution thereby visualizing mouse brain images with unprecedented detail. |
