| アイテムタイプ |
会議発表用資料 / Presentation(1) |
| 公開日 |
2026-05-15 |
| タイトル |
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タイトル |
Development of a total-body small-animal PET system: Demonstration of sub-second dynamic rat imaging |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6670 |
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資源タイプ |
conference poster |
| 著者 |
Hangyu Kang
Tashima Hideaki
Wakizaka Hidekatsu
Akamatsu Go
Iwao Yuma
Toramatsu Chie
Zhang Ming-Rong
Yamaya Taiga
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| 抄録 |
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内容記述 |
Objectives: For preclinical research, sub-second dynamic PET imaging is important to visualize cardiac and brain functions accurately. However, the temporal resolution of conventional preclinical PET has been limited to on the order of few seconds due to low sensitivity. In addition, conventional PET cannot cover the total-body of a rat due to short axial FOV thereby limiting total-body dynamic imaging. Here, we present an ultrasensitive small animal PET scanner for sub-second dynamic imaging of a rat with total-body coverage.Methods: The developed total-body small-animal PET scanner (TBS-PET) has a 155 mm inner diameter and 325.6 mm axial FOV. The TBS-PET consists of 6 rings, each of which has 10 DOI detectors. Each DOI detector consists of a 4-layer Zr-doped GSO (GSOZ) crystal array and an 8×8 array multi-anode PMT. Each crystal layer has a 16×16 array of GSOZ crystals (2.8×2.8×7.5 mm3) resulting in a total crystal thickness of 30 mm. The PMT anode signals are multiplexed with a resistive network and then digitized by a custom-made DAQ system. The physical performance was characterized in accordance with the NEMA NU4 standard. A resolution phantom was scanned at 30 mm radial offset position without and with DOI information. We performed sub-second dynamic rat imaging by administering 18F-FDG tracer via tail vein. All images were reconstructed by using OSEM algorithm.Results: The peak absolute sensitivity was 45.0% and noise equivalent count rate was 239 kcps with an energy window of 250-750 keV. The 2.2 mm rods were resolved clearly with DOI information. The cardiac function of a rat was obtained with a temporal resolution of 0.25 s. Conclusions: The TBS-PET enabled sub-second dynamic PET imaging of a rat with total-body coverage. We plan to perform parametric imaging by using image-derived input function for various radiopharmaceuticals. Finally, we plan to use the TBS-PET for ultralow dose imaging applications such as in-beam PET imaging and single-cell tracking. |
| 会議概要（会議名, 開催地, 会期, 主催者等） |
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内容記述 |
2026 SNMMI Annual Meeting |
| 発表年月日 |
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日付 |
2026-06-02 |
