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Unlocking the potential of large-scale 3D imaging with tissue clearing techniques
https://repo.qst.go.jp/records/2003245
https://repo.qst.go.jp/records/2003245ef4f1402-fc7f-473e-adc7-0d05af500d63
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2026-04-10 | |||||||
| タイトル | ||||||||
| タイトル | Unlocking the potential of large-scale 3D imaging with tissue clearing techniques | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
Susaki Etsuo
× Susaki Etsuo
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The three-dimensional (3D) anatomical structure of living organisms is intrinsically linked to their functions, yet modern life sciences have not fully explored this aspect. Recently, the combination of efficient tissue clearing techniques and light-sheet fluorescence microscopy for rapid 3D imaging has improved access to 3D spatial information in biological systems. This technology has found applications in various fields, including neuroscience, cancer research and clinical histopathology, leading to significant insights. It allows imaging of entire organs or even whole bodies of animals and humans at multiple scales. Moreover, it enables a form of spatial omics by capturing and analyzing cellome information, which represents the complete spatial organization of cells. While current 3D imaging of cleared tissues has limitations in obtaining sufficient molecular information, emerging technologies such as multi-round tissue staining and super-multicolor imaging are expected to address these constraints. 3D imaging using tissue clearing and light-sheet microscopy thus offers a valuable research tool in the current and future life sciences for acquiring and analyzing large-scale biological spatial information. | |||||||
| 書誌情報 |
Microscopy(Oxf) 巻 74, 号 3, p. 179-188, 発行日 2024-09 |
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| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2050-5701 | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1093/jmicro/dfae046 | |||||||
