| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-04-08 |
| タイトル |
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タイトル |
Defect-Activated and Surface-Modified Hexagonal Boron Nitride Nanoparticles toward Intracellular Quantum Sensing |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Suzune Shimomura
Yurina Nakane
Abe Hiroshi
Yusuke Miyake
Ohshima Takeshi
Yumi Yoshida
Kohji Maeda
Takuma Sugi
Shingo Sotoma
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
van der Waals materials hosting spin defects have emerged as a new platform for solid-state quantum sensing. We report hexagonal boron nitride (hBN) nanoparticles containing negatively charged boron vacancy (VB–) centers that function as nanoscale quantum sensors. High-energy electron irradiation efficiently generated VB– centers, enabling clear optically detected magnetic resonance (ODMR) detection from nanoparticle ensembles. To improve dispersion and suppress nonspecific protein adsorption, we developed a two-step surface modification process using silica encapsulation followed by hyperbranched polyglycerol (HPG) grafting. The HPG coating enhanced colloidal stability and reduced nonspecific protein adsorption. ODMR thermometry revealed temperature-dependent frequency shifts with a thermal coefficient of approximately – 300 kHz/°C. Finally, we demonstrated proof-of-concept detection of ODMR signal in HeLa cells after uptake of the nanoparticles. These results establish VB–-containing hBN nanoparticles as promising nanoscale quantum sensors for future intracellular applications. |
| 書誌情報 |
Nano Letters
巻 26,
号 11,
p. 3674-3680,
発行日 2026-04
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| 出版者 |
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出版者 |
ACS Pubilications |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1021/acs.nanolett.5c05398 |
