| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-04-03 |
| タイトル |
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タイトル |
Sub-0.5 mm resolution PET vs. autoradiography: Comparison of mGluR1 concentrations in mouse brain |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hangyu Kang
Tashima Hideaki
Wakizaka Hidekatsu
Minamihisamatsu Takeharu
Yamasaki Tomoteru
Fujinaga Masayuki
Zhang Ming-Rong
Higuchi Makoto
Yamaya Taiga
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
For mouse brain PET imaging with high quantification accuracy, ultrahigh resolution is essential. Metabotropic glutamate receptors are important molecular targets, linked to various neurological diseases. Here we report the in vivo mouse brain images obtained with sub-0.5 mm resolution PET in comparison with autoradiography using 4-18F-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide (18F-FITM) that binds to metabotropic glutamate receptor subtype 1.Methods: We recently developed a sub-0.5 mm resolution PET scanner having an axial coverage of 23.4 mm and inner diameter of 48 mm. The PET scanner comprises 32 depth-of-interaction (DOI) detectors, each of which has staggered 3-layer lutetium yttrium orthosilicate crystal arrays with a pitch of 0.8 mm. A resolution phantom was used to evaluate the imaging performance of the PET scanner. Dynamic PET imaging was performed to evaluate the concentration changes of 18F-FITM at various mouse brain regions. In vivo metabotropic glutamate receptor imaging of a mouse brain was performed using 18F-FITM and the PET scanner. Subsequently, autoradiography images of the same mouse brain were obtained using 18F-FITM.Results: The 0.45 mm rod structure was resolved with the PET scanner. Time-activity-curves of various mouse brain regions were obtained. The sub-0.5 mm resolution PET visualized the 18F-FITM uptakes of the mouse brain with high correlation to the autoradiography images.Conclusion: The sub-0.5 mm resolution PET can open up new opportunities for translational neuroscience research using mice models. |
| 書誌情報 |
Journal of Nuclear Medicine
発行日 2026-04
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| 出版者 |
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出版者 |
Society of Nuclear Medicine and Molecular Imaging |
