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Low-Cost Polyphenol-Polypyrrole Molecularly Imprinted Sensor for Point-of-Care Alzheimer's Detection.
https://repo.qst.go.jp/records/2003012
https://repo.qst.go.jp/records/20030129e02357a-b4ce-4097-9d5b-218a39f4005b
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||
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| 公開日 | 2026-03-13 | |||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||
| タイトル | Low-Cost Polyphenol-Polypyrrole Molecularly Imprinted Sensor for Point-of-Care Alzheimer's Detection. | |||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 著者 |
Ajith Mohan Arjun
× Ajith Mohan Arjun
× Sudhaunsh Deshpande
× Guoyi Liu
× Daimei Miura
× Krzysztof Pawlak
× Tokuda Takahiko
× Makoto Higuchi
× Miyu Matsumoto
× Tomoko Umemura
× Kaori Tsukakoshi
× Sanjiv Sharma
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| 抄録 | ||||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||
| 内容記述 | There is an urgent need for rapid, affordable diagnostics for Alzheimer's disease (AD), particularly those that can detect phosphorylated Tau 181 (p-tau181)─a key biomarker─directly in plasma. We present a scalable, label-free electrochemical biosensor fabricated on a printed circuit board platform, integrating a novel nanomolecularly imprinted polymer transducer based on a polyphenol red-polypyrrole composite. This platform enables sensitive detection of p-tau181 in undiluted plasma, serum, and clinical AD samples using a custom-designed potentiostat and machine learning-assisted classification. The sensor achieves a detection limit of 498 fg mL, a sensitivity of 8.99 μA/pg mL, and an area under the ROC curve (AUC) of 0.84 in clinical samples, comparable to the single molecule array (SIMOA) assay (AUC = 0.91), but at a fraction of the cost. This integrated platform, validated in real patient samples, demonstrates significant advancement toward accessible, point-of-care diagnostics for early AD detection. | |||||||||||||||||||||||||||
| 書誌情報 |
ACS sensors 巻 10, 号 11, p. 8435-8446, 発行日 2025-11 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 2379-3694 | |||||||||||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||||||||||
| 関連識別子 | 40814138 | |||||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||||||
| 関連識別子 | 10.1021/acssensors.5c01816 | |||||||||||||||||||||||||||
