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  1. 原著論文

Activation mapping in multi-center retrospective rat sensory-evoked functional MRI datasets using a unified pipeline

https://repo.qst.go.jp/records/2002953
https://repo.qst.go.jp/records/2002953
2bfaec51-ceb8-4d34-95c2-528c5330568f
アイテムタイプ 学術雑誌論文 / Journal Article(1)
公開日 2026-03-07
タイトル
タイトル Activation mapping in multi-center retrospective rat sensory-evoked functional MRI datasets using a unified pipeline
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Marie E Galteau

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Marie E Galteau

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Margaret Broadwater

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Margaret Broadwater

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Yi Chen

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Yi Chen

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Gabriel Desrosiers-Gregoire

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Gabriel Desrosiers-Gregoire

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Rita Gil

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Rita Gil

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Johannes Kaesser

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Johannes Kaesser

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Eugene Kim

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Eugene Kim

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Pervin Kıryağdı

× Pervin Kıryağdı

Pervin Kıryağdı

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Henriette Lambers

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Henriette Lambers

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Yanyan Y Liu

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Yanyan Y Liu

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Xavier López-Gil

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Xavier López-Gil

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Eilidh MacNicol

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Eilidh MacNicol

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Parastoo Mohebkhodaei

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Parastoo Mohebkhodaei

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Ricardo X N De Oliveira

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Ricardo X N De Oliveira

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Carolina A Pereira

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Carolina A Pereira

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Henning M Reimann

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Henning M Reimann

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Alejandro Rivera-Olvera

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Alejandro Rivera-Olvera

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Erwan Selingue

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Erwan Selingue

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Nikoloz Sirmpilatze

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Nikoloz Sirmpilatze

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Sandra Strobelt

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Sandra Strobelt

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Akira Sumiyoshi

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Akira Sumiyoshi

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Channelle Tham

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Channelle Tham

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Raul Tudela

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Raul Tudela

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Roël M Vrooman

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Roël M Vrooman

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Isabel Wank

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Isabel Wank

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Yongzhi Zhang

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Yongzhi Zhang

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Wessel A van Engelenburg

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Wessel A van Engelenburg

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Jürgen Baudewig

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Jürgen Baudewig

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Susann Boretius

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Susann Boretius

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Diana Cash

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Diana Cash

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M Mallar Chakravarty

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M Mallar Chakravarty

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抄録
内容記述タイプ Abstract
内容記述 Functional Magnetic Resonance Imaging (fMRI) in rodents is pivotal for understanding the mechanisms underlying Blood Oxygen Level-Dependent (BOLD) signals and phenotyping animal models of disorders, among other applications. Despite its growing use, comparing rodent fMRI results across different research sites remains challenging due to variations in experimental protocols. Here, we aggregated and analyzed 22 sensory-evoked rat fMRI datasets from 12 imaging centers, totaling scans from 220 rats, to get a snapshot of the current acquisitions in the field. This retrospective analysis highlights common practices and parameters to inform future cross-laboratory standardization efforts. We applied a standardized preprocessing pipeline and evaluated the impact of different hemodynamic response function models on group- and individual-level activity patterns. Our analysis revealed inter-dataset variability attributed to differences in experimental design, anesthesia protocols, and imaging parameters. We identified robust activation clusters in all (22/22) datasets. The comparison between stock human models implemented in software and rat-specific models showed significant variations in the resulting statistical maps. Our findings emphasize the necessity for standardized protocols and collaborative efforts to improve the reproducibility and reliability of rodent fMRI studies. We provide open access to all datasets and analysis code to foster transparency and further research in the field.
書誌情報 Imaging Neurosci (Camb)

巻 3, p. IMAG.a.157, 発行日 2025-09
ISSN
収録物識別子タイプ ISSN
収録物識別子 2837-6056
PubMed番号
識別子タイプ PMID
関連識別子 40995458
DOI
識別子タイプ DOI
関連識別子 10.1162/IMAG.a.157
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