WEKO3
アイテム
Unraveling emotion regulation: optical and mathematical dissection of complex neural population dynamics
https://repo.qst.go.jp/records/2002909
https://repo.qst.go.jp/records/20029091c1c2d35-0eda-4a46-b8e3-0e59b4ab6859
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2026-03-02 | |||||||
| タイトル | ||||||||
| タイトル | Unraveling emotion regulation: optical and mathematical dissection of complex neural population dynamics | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||||
| 資源タイプ | conference presentation | |||||||
| 著者 |
Agetsuma Masakazu
× Agetsuma Masakazu
|
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| 抄録 | ||||||||
| 内容記述 | Emotion regulation enables adaptive responses to environmental changes, and thus is critical for survival. The brain plays a central role in this process, with the prefrontal cortex serving as a key hub that coordinates emotional regulation by integrating external sensory information, interoceptive signals, and past experiences (i.e., memories). Although it has been proposed that neurons in the prefrontal cortex work together as a group for such complex processes, the mechanisms by which these neuronal populations store and process information for emotion regulation remain poorly understood. To address this point, we have been developing in vivo deep-brain two-photon imaging methods in mice, which enable imaging of brain regions implicated in emotion regulation (including the medial prefrontal cortex and the brainstem) at cellular resolution. We also integrated the imaging system with behavioral paradigms to monitor neural representations during emotion regulation, and combined them with machine learning-based analyses to dissect the underlying neural computation. In this talk, I will present our recent findings on neural population dynamics underlying fear memory. Specifically, I will discuss how our approach seeks to uncover the computations by which neural populations, organized into networks, give rise to fear memory encoding. | |||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||
| 内容記述 | The 7th International Symposium for Bioimaging | |||||||
| 発表年月日 | ||||||||
| 日付 | 2026-02-27 | |||||||
