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内容記述 |
To compare dose to the organ at risk (OAR) and target coverage of carbon-ion beam, protons, and photons for patientswith head and neck cancer. Treatment plans for carbon-ion pencil beam scanning (C-PBS) (64 Gy (RBE) in 16 fractions),proton pencil beam scanning (P-PBS), and volumetric modulated arc therapy (VMAT) (70 Gy in 35 fractions for P-PBSand VMAT) were generated and compared using different dose constraints per treatment modality. Dose metrics (e.g.D95,V20) were analyzed. Statistical significance was assessed by the Wilcoxon signed-rank test. Also, we investigatedhowmany normal tissues were irradiated above the constraint after achieving the planning goals (pass rate) in the OARs.C-PBS outperformed P-PBS and VMAT in PTV coverage (p=0.01 for both); however, P-PBS and VMAT did not dif-fer substantially from each another (p=0.35). C-PBS was superior in limiting the dose to the OAR. The pass rates forC-PBS, P-PBS, and VMAT were 94%, 81%, and 69%, respectively. C-PBS demonstrated superior performance comparedto VMAT and P-PBS in terms of dose conformation to the target volume and normal tissue sparing, and achieved thehighest pass rate in meeting dose constraints. |
