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Correction and utilization of the washout effect in range-verificationPET for particle therapy
https://repo.qst.go.jp/records/2001973
https://repo.qst.go.jp/records/200197347db37bf-6f3e-4f5c-aae6-750721615495
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2026-01-06 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Correction and utilization of the washout effect in range-verificationPET for particle therapy | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Toramatsu Chie
× Toramatsu Chie
× Yamaya Taiga
× Kanno Iwao
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | In charged particle therapy, it is essential to verify the irradiation beam range. Thus, using positron (β+)-emitting nuclideswhich are produced in irradiated tissue, positron emission tomography (PET) has been studied, and clinically applied forin vivo range verification in particle therapy. However, a correction method for the biological washout effect is one ofthe fundamental issues for quantitative verification of the beam range; the irradiation-induced β+-emitting nuclides areaffected by the pathophysiological environment such as blood perfusion. Since the biological washout effect is a tissue-specific phenomenon, extensive basic and clinical research has been conducted for modeling its kinetic process. Althoughconsidered as an undesirable factor in PET-based range validation, on the other hand, the biological washout effect mayprovide unique insights into the vascular status of a tumor and potentially support evaluation of the cancer pathophysiol-ogy. Consequently, this review provides a comprehensive outline of studies of the biological washout effect in particletherapy, focusing on both its correction and potential beneficial utilization. | |||||||||||
| 書誌情報 |
Radiological Physics and Technology 発行日 2026-01 |
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| 出版者 | ||||||||||||
| 出版者 | Springer Nature | |||||||||||
| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1007/s12194-025-01000-2 | |||||||||||
