| アイテムタイプ |
会議発表論文 / Conference Paper(1) |
| 公開日 |
2025-06-02 |
| タイトル |
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タイトル |
Directly Monitoring the Dynamic In Vivo Metabolisms of Hyperpolarized 13C Glutathione with Higher Molecular Weights by Breaking Intrinsic 13C T1 Boundaries |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_5794 |
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資源タイプ |
conference paper |
| アクセス権 |
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|
アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
Yamamoto Kazutoshi
Kondo Yohei
Saito Yutaro
Seki Tomohiro
Takakusagi Yoichi
Koyasu Norikazu
Saito Keita
Natarajan Raju
Rolf E. Swenson
Sando Shinsuke
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Profiling the metabolic and physiologic phenotypes of tumors has been increasingly important in treatment planning and response monitoring, where hyperpolarized MRI is a cutting-edge MR methodology to interrogate in vivo metabolisms non-invasively. This emerging technology has been intrinsically limited for molecules with smaller molecular weights(M.W.~ 200) due to limitations related to T1 spin-lattice relaxation times. Therefore, clinically promising peptide-based in vivo hyperpolarized probes with larger molecular weights have not been possible due to this long-standing limitation in their shorter lifetimes.Here, we demonstrate our rationally designed structural framework successfully enables us to directly observe in vivo metabolic activities of a tripeptide, glutathione(M.W. 300~), which has a central role in cellular metabolisms and redox status. The newly developed hyperpolarized 13C-GSH can report site-specific enzymatic activities in vivo and monitor treatment responses on tumor xenografts successfully.This framework will pave the way for the future development of hyperpolarized probes and tumor characterization, which can possibly lead to better prognostics, and earlier response monitoring in cancer treatment. |
| 書誌情報 |
Proc. ISMRM
巻 in press,
発行日 2025-05
|
