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内容記述 |
Rh-103m is one of the best radionuclides for Auger therapy (i.e., targeted radionuclide therapy using Auger emitters). A radioisotope generator (103Pd/103mRh generator) is a feasible tool to supply 103mRh owing to its short half-life (56 min). However, 103mRh generators reported previously have drawbacks such as low yield, large volume of recovered extractant, and long operation time. Therefore, we developed a new type of 103Pd/103mRh generator using 103Pd (without a carrier), which was adsorbed onto about 20 beads (3.7 mg of resin) of an anion-exchange resin (SA11AL), followed by 103mRh extraction. We also prepared conventional generator (using 2.7 g of resin) for performance comparison with the new type.The 103mRh produced by the conventional generator was 62 MBq. The new generator had a yield of up to 82 MBq. The yield of the new generator was 54 % ± 4 % compared with 37 % ± 1.9 % for the conventional one, and the product volume was 450 ± 40 µL compared with 5.9 ± 0.07 mL. Moreover, the operation time was reduced from 14 min to just 5 s. Although the new generator had a breakthrough that was about five times higher than that of the conventional one, the aforementioned benefits (i.e., minimizing volume of extract, shorter operation time, and higher yield of 103mRh) resulted in the concentration of 103mRh in the product fraction being about 19 times higher. In addition, the new generator was far smaller and could be handled with greater ease. |
