| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-16 |
| タイトル |
|
|
タイトル |
Structure of the C-terminal of viral responsive protein 15 (VRP15): a key protein during white spot syndrome virus (WSSV) infection. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Pasunee Laohawutthichai
Sun-Yong Kim
Min Fey Chek
Thapanan Jatuyosporn
Anchalee Tassanakajon
Kuakarun Krusong
Toshio Hakoshima
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
White spot syndrome virus (WSSV) is a major serious threat to black tiger shrimp farming. WSSV infection induces a host protein, viral responsive protein 15 (VRP15), for viral assembly and nuclear egress. Here, we showed that the C-terminal tail of VRP15 (VRP15-C) interacts directly with the viral nucleocapsid tegument protein WSV399. The crystal structure of VRP15-C was determined at 1.5Å. The structure showed that VRP15-C forms a dimer by forming an α-helix bundle structure and that the dimer further interacts with adjacent dimers to form a tetramer and a higher oligomer by intermolecular helix-helix interactions. The ability to form oligomeric forms may contribute to assembly of viral proteins to form a nucleocapsid of WSSV. |
| 書誌情報 |
Journal of molecular biology
発行日 2025-07
|
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
40639753 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jmb.2025.169329 |
