| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-11 |
| タイトル |
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タイトル |
Ultra-high dose rate protons in clinical irradiation suppress DNA single-strand breaks induction in the below nano-second time scale of physicochemical stages. |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Mamiya Taisei
Kusumoto Tamon
Sasai Kenzo
Kamiguchi Nagaaki
Amano Daizo
Kurita Kazuyoshi
Kodaira Satoshi
Konishi Teruaki
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Purpose: This study investigated the impact of ultra-high dose rate (UHDR) proton radiotherapy on DNA damage compared to conventional dose rate (CONV) radiotherapy. We hypothesized that the unique physicochemical processes associated with UHDR could lead to reduction of DNA damage.Materials and Methods: Plasmid DNA (pBR322, 4.3 kbp) was irradiated in Tris-HCl solution at three concentrations: 10 mM, 100 mM, and 900 mM. The dose rates used were 0.1 Gy/s (CONV) and 50 Gy/s (UHDR). Following irradiation, DNA single-strand breaks (SSBs) and double-strand breaks (DSBs) were quantified using agarose gel electrophoresis.Results: A significant reduction in SSB induction was observed only for DNA solution at the highest concentration (900 mM), which corresponds to a scavenging time of approximately 1 ns.Conclusions: These findings suggest that the suppression of SSB induction at UHDR is primarily due to rapid radical-radical reactions occurring within the first nano-second after irradiation. This study provides further insights into the potential benefits of UHDR radiotherapy for reducing healthy tissue damage. |
| 書誌情報 |
International Journal of Radiation Biology
発行日 2025-09
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| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1080/09553002.2025.2548470 |
