| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-18 |
| タイトル |
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タイトル |
Design of multi-ion therapy for head and neck cancers using carbon-, oxygen-, and neon-ion beams: potential efficacy against tumor hypoxia |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Masuda Takamitsu
Koto Masashi
Ikawa Hiroaki
Takei Hideyuki
Aoki Katsumi
Nakaji Taku
Kasamatsu Koki
Inaniwa Taku
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective. In order to initiate multi-ion therapy for head and neck cancers, it is necessary to predetermine the target dose-averaged linear energy transfer (LETd) prescription to the gross tumor volume (GTV). This study investigated LETd optimized treatment plans with carbon-, oxygen-, and neon-ion beams and demonstrated their potential efficacy against tumor hypoxia. Approach. Sixteen head and neck cancer patients with GTV sizes ranging from 5.5 to 143.1 cm3 were selected for this retrospective planning study. Carbon, oxygen, and neon ions were used alone or in combination with two ion species. The treatment plans were optimized to increase LETd within the GTV and to make the LETd distribution uniform while maintaining the relative biological effectiveness weighted dose distributions of conventional intensity modulated carbon-ion therapy (IMIT). The effective dose improvement rate against IMIT was then estimated by changing oxygen partial pressure within the GTV to 0 mmHg because a substantial number of anoxic cancer cells is predicted to exist in a hypoxic tumor microenvironment. Main results. The target LETd of 90 keV μm?1 was prescribable without deteriorating the dose distributions when: for example, carbon- and oxygen-ion beams were used for small tumors (around 20 cm3); oxygen-ion beams alone were used for medium tumors (around 50 cm3); and carbon- and neon-ion beams were used for large tumors (around 100 cm3). The uniformity of the LETd distributions within the GTV was about 10%. With the LETd prescription, the improvement rate of the effective dose covering 98% (i.e.
) of the GTV against anoxic cancer cells was about 30%. Significance. For the application to the first multi-ion therapy program, the target LETd prescription to the GTV was determined to be 90 keV μm?1. If tumor hypoxia contributes to the cause of recurrence, the proposed treatment may offer better local tumor control without compromising normal tissue sparing. |
| 書誌情報 |
Physics in Medicine & Biology
巻 70,
号 8,
p. 085003,
発行日 2025-04
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| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1088/1361-6560/adc5d6 |
