| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-04 |
| タイトル |
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タイトル |
Radiation Adverse Outcome pathways (AOPs): examining priority questions from an international horizon-style exercise. |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Vinita Chauhan
Danielle Beaton
Knut Erik Tollefsen
Julian Preston
Julie J Burtt
Julie Leblanc
Nobuyuki Hamada
Edouard I Azzam
Olivier Armant
Simon Bouffler
Omid Azimzadeh
Simone Moertl
Yutaka Yamada
Ignacia B Tanaka
Jan Christian Kaiser
Kimberly Applegate
Dominique Laurier
Jacqueline Garnier-Laplace
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The Organisation for Economic Co-operation and Development (OECD) Adverse Outcome Pathway (AOP) Development Programme is being explored in the radiation field, as an overarching framework to identify and prioritize research needs that best support strengthening of radiation risk assessment and risk management strategies. To advance the use of AOPs, an international horizon-style exercise (HSE) was initiated through the Radiation/Chemical AOP Joint Topical Group (JTG) formed by the OECD Nuclear Energy Agency (NEA) High-Level Group on Low Dose Research (HLG-LDR) under the auspices of the Committee on Radiological Protection and Public Health (CRPPH). The intent of the HSE was to identify key research questions for consideration in AOP development that would help to reduce uncertainties in estimating the health risks following exposures to low dose and low dose-rate ionizing radiation. The HSE was conducted in several phases involving the solicitation of relevant questions, a collaborative review of open-ended candidate questions and an elimination exercise that led to the selection of 25 highest priority questions for the stated purpose. These questions were further ranked by over 100 respondents through an international survey. This final set of questions was judged to provide insights into how the OECD's AOP approach can be put into practice to meet the needs of hazard and risk assessors, regulators, and researchers. This paper examines the 25 priority questions in the context of hazard/risk assessment framework for ionizing radiation. |
| 書誌情報 |
International Journal of Radiation Biology
巻 100,
号 7,
p. 982-995,
発行日 2024-05
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1362-3095 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
38718325 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1080/09553002.2024.2348072 |
