| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-07 |
| タイトル |
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|
タイトル |
Significance of androgen-deprivation therapy for intermediate- and high-risk prostate cancer treated with high-dose radiotherapy: A literature review. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Rihito Aizawa
Hitoshi Ishikawa
Manabu Kato
Shosei Shimizu
Takashi Mizowaki
Yasuo Kohjimoto
Shiro Hinotsu
Isao Hara
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The real-world benefits of adding androgen-deprivation therapy (ADT) and its optimal duration when combined with current standard high-dose radiation therapy (RT) remain unknown. We aimed to assess the efficacy of and toxicities associated with ADT in the setting of combination with high-dose RT for intermediate-risk (IR) and high-risk (HR) prostate cancer (PCa). This article is a modified and detailed version of the commentary on Clinical Question 8 described in the Japanese Clinical Practice Guidelines for Prostate Cancer (ver. 2023). A qualitative systematic review was performed according to the Minds Guide. All relevant published studies between September 2010 and August 2020, which assessed the outcomes of IR or HR PCa treated with high-dose RT, were screened using two databases (PubMed and ICHUSHI). A total of 41 studies were included in this systematic review, mostly consisting of retrospective studies (N?=?34). The evidence basically supports the benefit of adding ADT to high-dose RT to improve tumor control. Regarding IR populations, many studies suggested the existence of a subgroup for which adding ADT had no impact on either overall survival or the BF-free duration. On the other hand, regarding HR populations, several studies suggested the positive impact of adding ADT for ?1?year on overall survival. Adding ADT increases not only the risk of sexual dysfunction but also that of cardiovascular toxicities or bone fracture. Although the benefit of adding ADT was basically suggested for both IR and HR populations, further investigations are warranted to identify subgroups of patients for whom ADT has no benefit, as well as the appropriate duration of ADT for those who do derive benefit. |
| 書誌情報 |
International journal of urology : official journal of the Japanese Urological Association
巻 31,
号 10,
p. 1068-1079,
発行日 2024-10
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| 出版者 |
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出版者 |
Blackwell Science Asia |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1442-2042 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
39021064 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1111/iju.15535 |
