| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-25 |
| タイトル |
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タイトル |
Remote Cortical Network for Frontal Cognitive Symptoms derived from Tau Accumulation in Progressive Supranuclear Palsy |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hori Yuki
Endo Hironobu
Tagai Kenji
Kataoka Yuko
Goto Ryoji
Kurose Shin
Momota Yuki
Kokubo Naomi
Seki Chie
Moriguchi Sho
Shimada Hitoshi
Shinoto Hitoshi
Tokuda Takahiko
Takahata Keisuke
Minamimoto Takafumi
Higuchi Makoto
Hirabayashi Toshiyuki
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder characterized by movement impairments and frontal cognitive dysfunctions. While motor symptoms are linked with subcortical tau deposits, mechanisms underlying the frontal cognitive symptoms remain unclear due to limited tau accumulation in the frontal cortex and heterogeneous tau distribution. Here, we combined high-contrast tau PET with normative connectome to identify a common network extended from tau deposits underlying the frontal cognitive symptoms in PSP. Regions with tau deposition were connected to a common cortical network that was not detectable through atrophy-based analyses. This network was primarily overlapped with canonical action-mode and frontoparietal networks. While the degree of subcortical tau deposition or atrophy correlated with motor symptoms, only connectivity between tau deposition sites and the derived cortical network explained the frontal cognitive deficits. These findings propose network mechanisms underlying frontal cognitive impairments in PSP, emphasizing the role for remote effects of pathological tau deposits. |
| 書誌情報 |
bioRxiv.
発行日 2025-02
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| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1101/2025.02.05.636578 |
