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Comparative elemental analysis of collagen vascular-associated lung diseases by in-air micro- PIXE, a pilot study
https://repo.qst.go.jp/records/2001488
https://repo.qst.go.jp/records/2001488ad4c8ad5-5521-4026-b02f-68e1e3e076b9
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2025-02-26 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Comparative elemental analysis of collagen vascular-associated lung diseases by in-air micro- PIXE, a pilot study | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
Yasuhiko Koga (群馬大学)
× Yasuhiko Koga (群馬大学)
× Satoh Takahiro
× Yamagata Ryohei
× Ishii Yasuyuki
× Wataru Kada (東北大学)
× Takeshi Hisada (群馬大学)
× Kunio Dobashi (上武呼吸器科内科病院)
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Background: Collagen vascular disease (CVD) is a systemic disease in which connective tissue abnormalities of systemic organs such as the skin, kidneys, lungs, and lymph nodes are caused by abnormal functions of the immune system. The cause of CVD has not been clarified yet, but it has been suggested that exposure to heavy metals and silica may be the cause of vasculitis and systemic sclerosis. Purpose: In this study, we focused on the elemental analysis of lung tissues complicated with collagen vascular disease-associated interstitial lung disease (CVD-ILD) and investigated the relationship between inhaled elements and CVD-ILD. Methods: We examined the inhaled elements in the lungs using in-air micro-particle-induced X-ray emission analysis (in-air micro-PIXE). Elemental analysis of lung tissue specimens was performed by using 5 cases of systemic sclerosis and 3 cases of aminoacyl-tRNA synthetase (ARS) antibody-positive dermatomyositis surgically resected by thoracoscopic lung biopsy. Control lung samples were obtained from early-stage lung cancer patients. The relative amounts of each elements divided with sulfur in the lung was statistically analyzed. Results: There was a significant difference between CVD-ILD and the control lung in terms of inhaled silica/silicates. Furthermore, relative silica deposition was higher in scleroderma lungs compared to control lungs, but not in lungs from ARS-positive cases. Conclusion: These results indicated that silica deposition in lung tissue may be involved in the pathogenesis of CVD-ILD, especially systemic sclerosis. |
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| 書誌情報 |
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 巻 561, p. 16534, 発行日 2025-04 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 0168-583X | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | 10.1016/j.nimb.2025.165634 | |||||||||||||||||||
